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The disputed ‘spoonful of plastic in your brain’ study

A Nature Medicine paper reported plastic in every brain tested, rising over time, but its method and headline figure are strongly contested.

Authors / organisation
Nihart A.J., Garcia M.A., El Hayek E. et al.
Year
2025
Journal or publisher
Nature Medicine
Digital object identifier (DOI)
10.1038/s41591-024-03453-1
Study type
Cross-sectional
Evidence strength
Evidence: Contested
Sample / scope
52 post-mortem brains from one US state (28 from 2016, 24 from 2024)
Key finding
Reported plastic in every brain, at levels far above liver and kidney, rising between 2016 and 2024 and higher in dementia cases.
Headline number
About 4,900 µg/g reported in 2024 brains (disputed)
Caveats / how it is misquoted
Heavily contested: pyrolysis gas chromatography–mass spectrometry (pyrolysis-GC-MS) may misread brain lipids as polyethylene; weak contamination controls; author correction for duplicated images; a 2026 spectroscopy study (Li et al., Nature Health) found levels about 100× lower. Do not use the 'spoonful of plastic' figure.
Open access
Yes
Verified on
22 September 2026

The Campen laboratory at the University of New Mexico analysed 52 post-mortem brains (28 from 2016 and 24 from 2024) using pyrolysis gas chromatography mass spectrometry, along with liver and kidney samples from the same donors.

They reported polyethylene as the dominant plastic, concentrations in brain far higher than in liver or kidney, a significant rise between 2016 and 2024, and higher levels in 12 people who had died with dementia. The average of about 4,900 micrograms per gram in 2024 brains was widely reported as 'a spoonful of plastic in your brain'.

Independent scientists have raised serious objections. The pyrolysis method can mistake brain fats for polyethylene; more than 10% of brain tissue was left undigested compared with under 1% for other organs; contamination controls were weak; and the authors issued a correction for duplicated supplementary images. A 2026 study using spectroscopic particle counting found levels roughly 100 times lower.

Site guidance: do not use the 'spoon of plastic' figure. Say instead that plastic particles have been detected in virtually every brain sample tested, and that how much, and whether it causes harm, remains unresolved.

Sources last verified 22 September 2026. Page updated 23 September 2026. How we check sources